| Description | 4-Phenoxybenzylamine inhibits the function of the NS3 protein by stabilizing an inactive conformation with an IC50 of about 500 μM against HCV NS3/4a . |
| In vitro | 在丙型肝炎病毒（HCV）NS3蛋白的蛋白酶与解旋酶域之间的界面处，识别出一个高度保守的新型结合位点。4-Phenoxybenzylamine在该异构位点的结合，通过稳定非活性构象来抑制NS3蛋白的功能，因此它代表了一类新型直接作用抗病毒化合物。 |
| Target activity | HCV NS3/4A:500 μM |
| molecular weight | 199.25 |
| Molecular formula | C13H13NO |
| CAS | 107622-80-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 30 mg/mL (150.56 mM) |
| References | 1. Saalau-Bethell S M , Woodhead A J , Chessari G , et al. Discovery of an allosteric mechanism for the regulation of HCV NS3 protein function[J]. Nature Chemical Biology, 2012, 8(11):2354. |