| Description | 4-Nitrobenzoic acid (4Nitrobenzoic acid) is a pharmaceutical intermediate often found in the production of folic acid, DABA, PABA and dyes. |
| Target activity | A549 cells:5.3 µM, HT29 cells:8.4 µM |
| Synonyms | Kyselina p-nitrobenzoova, 4Nitrobenzoic acid, Nitrodracylic acid, 4 Nitrobenzoic acid |
| molecular weight | 167.12 |
| Molecular formula | C7H5NO4 |
| CAS | 62-23-7 |
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 55 mg/mL (329.1 mM) |
| References | 1. Smith G. The structures of the isomorphous potassium and rubidium salts of 4-nitrobenzoic acid and an overview of the metal complex stereochemistries of the alkali metal salt series with this ligand. Acta Crystallogr C Struct Chem. 2015 Jun;71(Pt 6):499-505. 2. Smith G. Hydrogen-bonded two- and three-dimensional polymeric structures in the ammonium salts of 3,5-dinitrobenzoic acid, 4-nitrobenzoic acid and 2,4-dichlorobenzoic acid. Acta Crystallogr C Struct Chem. 2014 Mar;70(Pt 3):315-9. 3. Selvakumar E, et al. Synthesis, growth and spectroscopic investigation of an organic molecular charge transfer crystal: 8-hydroxy quinolinium 4-nitrobenzoate 4-nitrobenzoic acid. Spectrochim Acta A Mol Biomol Spectrosc. 2014 Jan 3;117:259-6 4. Kuzniar EJ, et al. Influence of the gut microflora on the metabolism of 4-nitrobenzoic acid in the marmoset. Xenobiotica. 1981 Oct;11(10):675-83. 5. National Toxicology Program . NTP Toxicology and Carcinogenesis Studies of p-Nitrobenzoic Acid (CAS No. 62-23-7) in F344/N Rats and B6C3F1 Mice (Feed Studies). Natl Toxicol Program Tech Rep Ser. 1994;442:1-306. 6. Ashok D, et al. Synthesis and anticancer activity evaluation of (E)-3-{[5-(aryl)-1, 3, 4-oxadiazol-2-yl] methyl}-5-(3, 4, 5-trimethoxybenzylidene) thiazolidine-2, 4-diones[J]. Russian Journal of General Chemistry. 2016; 86: 681-685. |