| Description | (4-Acetamidocyclohexyl) nitrate (BM121307) is an activator of guanylate cyclase. |
| In vivo | The elimination of BM121307 and its metabolites via urine and feces amount to 76.5% after oral application, and to 80.7% of the applied dose after intravenous application. The major amount of radioactivity is eliminated via urine (69.4% and 73.6% of the dose, respectively), whereas the fecal elimination is found to be negligible. Investigations of the urinary samples show that the drug is metabolized to a high percentage of trans-N-(4-Hydroxycyclohexyl) acetamide is the main metabolite. |
| Synonyms | BM121307 |
| molecular weight | 202.21 |
| Molecular formula | C8H14N2O4 |
| CAS | 137213-91-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Zell C, et al. Biotransformation of the organic nitrate trans-N-(4-nitroxycyclohexyl)acetamide in dogs. Arzneimittelforschung. 1994 Sep;44(9):1021-8. |