| Description | 3-Phenylpropyl isothiocyanate exhibits a potent inhibitory effect on N-nitrosomethyl-benzylamine (NMBA) tumorigenesis, thereby displaying strong chemopreventive properties [1] [2]. |
| In vivo | 3-Phenylpropyl isothiocyanate (5、1或0.2 μmol；灌胃；A/J小鼠；在通过i.p.注射给予10 μmol NNK之前连续4天每天一次)有效地抑制了NNK诱导的肺肿瘤。在体内，3-Phenylpropyl isothiocyanate减少了由苯并[a]芘和NNK [3]诱发的肺肿瘤形成。 |
| molecular weight | 177.27 |
| Molecular formula | C10H11NS |
| CAS | 2627-27-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 50 mg/mL (282.06 mM) |
| References | 1. Morse MA, et al. Structure-activity relationships for inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone lung tumorigenesis by arylalkyl isothiocyanates in A/J mice. Cancer Res. 1991;51(7):1846-1850. 2. Nishikawa A, et al. Chemopreventive effects of 3-phenylpropyl isothiocyanate on hamster lung tumorigenesis initiated with N-nitrosobis(2-oxopropyl)amine. Jpn J Cancer Res. 1996;87(2):122-126. 3. Stephen S Hecht, et al. Inhibition of lung tumorigenesis in A/J mice by N-acetyl-S-(N-2-phenethylthiocarbamoyl)-L-cysteine and myo-inositol, individually and in combination. Carcinogenesis.2002 Sep;23(9):1455-61. |