| Description | 3-demethylcolchicine is a natural product isolated from Gloriosa superba.Inhibitory effect on the polymerization of purified bovine brain tubulin. |
| In vitro | 3-demethylcolchicine 在体外和体内显示了显著效果，特别是在小鼠P388淋巴细胞性白血病筛查中，对其毒性以及与微管蛋白结合方面表现出显著效果。 |
| Synonyms | 3-去甲秋水仙碱, 3-去甲基秋水仙碱 |
| molecular weight | 385.41 |
| Molecular formula | C21H23NO6 |
| CAS | 7336-33-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 10 mg/mL (25.95 mM) |
| References | 1. M Rösner, H G Capraro, A E Jacobson.et al. Biological effects of modified colchicines. Improved preparation of 2-demethylcolchicine, 3-demethylcolchicine, and (+)-colchicine and reassignment of the position of the double bond in dehydro-7-deacetamidocolchicines.J Med Chem. 1981 Mar;24(3):257-61. |