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3-(2,6-dichlorobenzyl)-1-hexadecyl-2-methyl-1H-imidazol-3-ium iodide

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3-(2,6-dichlorobenzyl)-1-hexadecyl-2-methyl-1H-imidazol-3-ium iodide is a potent inhibitor of fructose-1,6-bisphosphate
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Description 3-(2,6-dichlorobenzyl)-1-hexadecyl-2-methyl-1H-imidazol-3-ium iodide is a potent inhibitor of fructose-1,6-bisphosphate aldolase.
In vivo 在小鼠中,通过抑制醛糖酶的活性可激活肝脏中的AMPK活性。在喂食高脂饮食的肥胖小鼠中,3-(2,6-dichlorobenzyl)-1-hexadecyl-2-methyl-1H-imidazol-3-ium iodide(口服,1 mg/kg,每天一次,持续两周)能有效地抑制醛糖酶活性,并激活小鼠肝脏中的AMPK活性。
molecular weight 593.45
Molecular formula C27H43Cl2IN2
Storage Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility DMSO: 60 mg/mL (101.1 mM)
References 1. By Deng, Xianming; Lin, Shengcai; Zhang, Chensong From PCT Int. Appl. (2018), WO 2018184561 A1 20181011.