| Description | (2R)-Octyl-α-hydroxyglutarate ((2R)-Octyl-2-HG) is a D-isomer 2-Hydroxyglutarate modified form. |
| In vitro | Treatment of IDH1-WT HeLa cells with (2R)-octyl-α-hydroxyglutaric acid (a modified form of 2-hydroxyglutaric acid with high cellular uptake) results in a dose-dependent DSB in log phase cells increase. It has been used to examine the contribution of D-2-hydroxyglutarate to the oxidative mitochondrial process of IDH1 mutant cancer cells. |
| Synonyms | (2R)-Octyl-2-HG |
| molecular weight | 260.33 |
| Molecular formula | C13H24O5 |
| CAS | 1391194-67-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 100 mg/mL (384.13 mM), Sonication is recommended. |
| References | 1. Sulkowski PL, et al. 2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologousrecombination and induces PARP inhibitor sensitivity. Sci Transl Med. 2017 Feb 1;9(375). |