| Description | (2R,4R)-APDC is a selective group II metabotropic glutamate receptors (mGluRs) agonist. It has anticonvulsant and neuroprotective effects. |
| In vivo | (2R,4R)-APDC (1-10 nmol; ICV; daily for 14 days) decreases cell proliferation in the dentate gyrus [2]. |
| Animal experiments | Animal Model: Adult male Sprague-Dawley rats weighing between 300 and 350 g. Dosage: 1 nmol/10 μl; 10 nmol/10μl. Administration: ICV; daily for 14 days [2] |
| molecular weight | 174.15 |
| Molecular formula | C6H10N2O4 |
| CAS | 169209-63-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Folbergrová J, et al. Posttreatment with group II metabotropic glutamate receptor agonist 2R,4R-4-aminopyrrolidine-2,4-dicarboxylate is only weakly effective on seizures in immature rats. Brain Res. 2009 Jun 1;1273:144-54. 2. Yao H, et al. 2R, 4R-APDC decreases cell proliferation in the dentate gyrus of adult rats: the effect of 2R, 4R-APDC on cell proliferation. Neuroreport. 2007 Sep 17;18(14):1459-62. |