| Description | 20-HETE promotes cell proliferation and migration in cancer and can be used to study prostate tumors and cardiac hypertrophy by activating the protein kinase C pathway to increase FBXO10 expression.20-HETE promotes cell proliferation and migration in cancer and can be used to study prostate tumors and cardiac hypertrophy by activating the protein kinase C pathway. |
| In vitro | 17-ODYA（1 μM）增加了大电导 Ca（2+）激活的 K+ 通道的活性，并且这种效应被 20-HETE 逆转（10 nM）。20-HETE（1-1000nM）将大鼠分离灌注的小肾动脉的直径减小约15%，TEA（1mM）阻断血管收缩剂对 20-HETE 的反应（100nM）[1]。 |
| In vivo | 20-HETE 有助于 DHT 诱导的血管重塑，与血压升高无关[2]。 |
| Synonyms | 20-hydroxy Arachidonic Acid |
| molecular weight | 320.47 |
| Molecular formula | C20H32O3 |
| CAS | 79551-86-3 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 2 mg/mL (6.24 mM), Sonication is recommended. Ethanol: 5 mg/mL (15.60 mM), Sonication is recommended. |
| References | 1. Zou AP, et al. 20-HETE is an endogenous inhibitor of the large-conductance Ca(2+)-activated K+ channel in renal arterioles. Am J Physiol. 1996 Jan;270(1 Pt 2):R228-37. 2. Ding Y, et al. 20-HETE induces remodeling of renal resistance arteries independent of blood pressure elevation in hypertension. Am J Physiol Renal Physiol. 2013 Sep 1;305(5):F753-63. 3. Lai G, et al. 20-HETE induces hyperglycemia through the cAMP/PKA-PhK-GP pathway. Mol Endocrinol. 2012 Nov;26(11):1907-16. |
| Citations | 1. Li B, Ma Y, Tan L, et al. 20-Hydroxytetraenoic acid induces hepatic fibrosis via the TGF-β1/Smad3 signaling pathway. Toxicology Letters. 2022 |