| Description | 2-Hydroxybenzylamine, a potent small molecule scavenger of IsoLGs, sequesters the reactive species as inert adducts. 2-Hydroxybenzylamine may be used to decrease early recurrence of atrial fibrillation and other atrial arrhythmias following atrial fibrillation ablation by decreasing IsoLG adducts with native biomolecules. |
| In vivo | 与治疗组（接受4-Hydroxybenzylamine或载体处理）相比，Ldlr-/-高胆固醇血症小鼠使用2-Hydroxybenzylamine后在不改变血浆胆固醇水平的情况下，面对主动脉粥样硬化程度降低了60%。采用2-Hydroxybenzylamine处理的Ldlr-/-小鼠显示出MDA-LDL与MDA-HDL水平降低，且其HDL在降低巨噬细胞胆固醇方面的能力增强。值得注意的是，相较于4-Hydroxybenzylamine，2-Hydroxybenzylamine能显著减少粥样硬化主动脉中的MDA-和IsoLG-lysyl含量。此外，2-Hydroxybenzylamine还能减轻炎症、减少斑块中的凋亡细胞、促进死细胞的有效清除，并且促进稳定斑块的特征表现。使用2-Hydroxybenzylamine作为二羰基清除剂，在小鼠家族性高胆固醇血症模型中展现出多重抗动脉硬化效应。 |
| molecular weight | 123.15 |
| Molecular formula | C7H9NO |
| CAS | 932-30-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 45 mg/mL (365.39 mM) |
| References | 1. O'Neill MJ, et al. 2-Hydroxybenzylamine (2-HOBA) to prevent early recurrence of atrial fibrillation after catheter ablation: protocol for a randomized controlled trial including detection of AF using a wearable device. Trials. 2021 Aug 28;22(1):576. 2. Tao H, et al. Scavenging of reactive dicarbonyls with 2-hydroxybenzylamine reduces atherosclerosis in hypercholesterolemic Ldlr-/- mice. Nat Commun. 2020 Aug 14;11(1):4084. |