2-heptyl-3-hydroxy-4(1H)-Quinolone Bioactivity,Chemical Properties,Storage & Solubility Information Pathways-PeptideDB

Description	2-heptyl-3-hydroxy-4(1H)-Quinolone (Pseudomonas Quinolone Signal) is a quorum-sensing signalling molecule produced by Pseudomonas aeruginosa in response to increased cell density. It increases the expression of the lasB gene in P. aeruginosa, the secretion of the metabolites pyocyanin and the lectin PA-IL, as well as increasing biofilm production in P. aeruginosa populations. It also reduces the iron content of the P. aeruginosa growth medium when used at a concentration of 40 μM and acts as an iron chelator in iron sulphate solutions.
In vitro	2-heptyl-3-hydroxy-4(1H)-Quinolone (60 µM) 使得 P. aeruginosa 群体中的代谢产物吡咯赤藓酮和凝集素PA-IL的分泌增加，并且促进生物膜的产生。[2] 而当浓度达到40 µM时，2-heptyl-3-hydroxy-4(1H)-Quinolone 能够降低 P. aeruginosa 生长培养基中的铁水平，并且在Fe(III)-硫酸溶液中作为铁螯合剂。[3]
Synonyms	2-heptyl-3-hydroxy-4(1H)-Quinolone, PQS, Pseudomonas Quinolone Signal
molecular weight	259.34
Molecular formula	C16H21NO2
CAS	108985-27-9
Storage	store at low temperature,store under nitrogen \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility	Methanol: Soluble DMSO: 12 mg/mL (46.27 mM)
References	1. Pesci EC, et al. Quinolone signaling in the cell-to-cell communication system of Pseudomonas aeruginosa. Proc Natl Acad Sci U S A. 1999 ; 96(20):11229-11234. 2. Diggle SP, et al. The Pseudomonas aeruginosa quinolone signal molecule overcomes the cell density-dependency of the quorum sensing hierarchy, regulates rhl-dependent genes at the onset of stationary phase and can be produced in the absence of LasR. Mol Microbiol. 2003 ; 50(1):29-43. 3. Bredenbruch F, et al. The Pseudomonas aeruginosa quinolone signal (PQS) has an iron-chelating activity. Environ Microbiol. 2006 ; 8(8):1318-1329.

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2-heptyl-3-hydroxy-4(1H)-Quinolone

CAS No.: 108985-27-9