| Description | 2-Desoxy-4-epi-pulchellin has potent in vitro cytotoxicities against the K562, MCF-7, Hela, DU145, U937, H1975, SGC-7901, A549, MOLT-4, and HL60 cell lines with IC50 values ranging from 0.10 to 46.7uM, while it shows significant antiviral (H1N1 and H3N2) activities, it also displays significant antimycobacterial activity (IC50=7.6 uM). |
| In vitro | Dicarabrol（1）及三种已知倍半萜（2-4）对K562、MCF-7、Hela、DU145、U937、H1975、SGC-7901、A549、MOLT-4和HL60细胞系展示出强大的体外细胞毒性，IC50值范围为0.10至46.7 μM。同时，它们对抗病毒（H1N1与H3N2）活性显著。此外，化合物1、3和4对抗结核菌活性也表现显著（IC50分别为3.7、6.0和7.6 μM）。 |
| molecular weight | 250.33 |
| Molecular formula | C15H22O3 |
| CAS | 122872-03-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 55 mg/ml (219.74 mM) |
| References | 1. Dicarabrol, a new dimeric sesquiterpene from Carpesium abrotanoides L. Bioorg Med Chem Lett. 2015 Oct 1;25(19):4082-4. |