| Description | 2-Deoxy-D-galactose is a glucose analog and glucose antagonist that inhibits the maintenance of hippocampal LTP and can suppress tumor growth by inhibiting the glycolytic process. |
| In vitro | 2-Deoxy-D-galactose 在 30 分钟内能迅速磷酸化，2-Deoxy-D-galactose（1mM/L）孵育 5 小时后，2-脱氧-D-半乳糖1-磷酸的含量达到了 35 毫摩尔每千克细胞[4]。 |
| In vivo | 在成年雄性 Wistar 大鼠的被动回避反应（PAR）习得试验中，2-Deoxy-D-galactose（2、4 和 8 μM；侧脑室内注射；2-8 μM；一次性）在 4 μM剂量下表现出 PAR 破坏作用[3]。 |
| molecular weight | 164.16 |
| Molecular formula | C6H12O5 |
| CAS | 1949-89-9 |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | H2O: 200 mg/mL (1218 mM), Sonication is recommended. Methanol: 100 mg/mL (609.16 mM), Sonication is recommended. |
| References | 1. Keppler DO, et al. The trapping of uridine phosphates by D-galactosamine. D-glucosamine, and 2-deoxy-D-galactose. A study on the mechanism of galactosamine hepatitis. Eur J Biochem. 1970 Dec;17(2):246-53. 2. Krug M, et al. The amnesic substance 2-deoxy-D-galactose suppresses the maintenance of hippocampal LTP. Brain Res. 1991 Feb 1;540(1-2):237-42. 3. Lorenzini CG, et al. 2-Deoxy-D-galactose effects on passive avoidance memorization in the rat. Neurobiol Learn Mem. 1997 Nov;68(3):317-24. 4. Smith DF, Keppler DO. 2-Deoxy-D-galactose metabolism in ascites hepatoma cells results in phosphate trapping and glycolysis inhibition. Eur J Biochem. 1977 Feb 15;73(1):83-92. |