| Description | 2-ATHBI is a S1P lyase inhibitor. |
| Synonyms | 1-[5-[(1R,2S,3R)-1,2,3,4-四羟基丁基]-1H-咪唑-2-基]乙酮, THI |
| molecular weight | 230.22 |
| Molecular formula | C9H14N2O5 |
| CAS | 94944-70-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 60 mg/ml (260.62 mM) |
| References | 1. Wang L, Ren B, Liu Y, Lu Y, Chang F, Yang L. 2-acetyl-4-tetrahydroxybutylimidazole and 4-methylimidazole in caramel colours, vinegar and beverages in China. Food Addit Contam Part B Surveill. 2015;8(3):163-8. doi: 10.1080/19393210.2015.1027286. Epub 2015 May 8. PubMed PMID: 25832559. 2. Elsinghorst PW, di Salvo ML, Parroni A, Contestabile R. Inhibition of human pyridoxal kinase by 2-acetyl-4-((1R,2S,3R)-1,2,3,4-tetrahydroxybutyl)imidazole (THI). J Enzyme Inhib Med Chem. 2015 Apr;30(2):336-40. doi: 10.3109/14756366.2014.915396. Epub 2014 Jun 5. PubMed PMID: 24899377. 3. Wang J, Schnute WC. Simultaneous quantitation of 2-acetyl-4-tetrahydroxybutylimidazole, 2- and 4-methylimidazoles, and 5-hydroxymethylfurfural in beverages by ultrahigh-performance liquid chromatography-tandem mass spectrometry. J Agric Food Chem. 2012 Feb 1;60(4):917-21. doi: 10.1021/jf204476x. Epub 2012 Jan 18. PubMed PMID: 22224586. 4. Ohtoyo M, Tamura M, Machinaga N, Muro F, Hashimoto R. Sphingosine 1-phosphate lyase inhibition by 2-acetyl-4-(tetrahydroxybutyl)imidazole (THI) under conditions of vitamin B6 deficiency. Mol Cell Biochem. 2015 Feb;400(1-2):125-33. doi: 10.1007/s11010-014-2268-z. Epub 2014 Nov 9. PubMed PMID: 25381637. |