| Description | 2,5-Dihydroxybenzaldehyde (Gentisaldehyde) has antioxidant activity against Mycobacterium avium subsp. Paratuberculosis. 2,5-Dihydroxybenzaldehyde also inhibits S. aureus strains(MIC50: 500 mg/L). |
| In vitro | 2,5-Dihydroxybenzaldehyde通过整合到单层中，形成抗菌脂质复合物的聚集体，降低了脂质的排列效率，提高了膜的流动性，并改变了单层膜模型中的总偶极矩，从而修改了三种脂质单层结构。2,5-Dihydroxybenzaldehyde与细菌磷脂的相互作用既取决于抗菌剂的结构，也取决于单层的组成[1]。 |
| Target activity | S. aureus:500 mg/L(MIC50) |
| Synonyms | Gentisaldehyde, 2,5-二羟基苯甲醛 |
| molecular weight | 138.12 |
| Molecular formula | C7H6O3 |
| CAS | 1194-98-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 30 mg/ml (217.20 mM) |
| References | 1. Nowotarska SW, et al. Effect of structure on the interactions between five natural antimicrobial compounds and phospholipids of bacterial cell membrane on model monolayers. Molecules. 2014 Jun 6;19(6):7497-515. 2. Bisht GS, et al. Diffusion-free mediator based miniature biofuel cell anode fabricated on a carbon-MEMS electrode. Langmuir. 2012 Oct 2;28(39):14055-64. 3. Schabauer A, et al. Gentisaldehyde and Its Derivative 2,3-Dihydroxybenzaldehyde Show Antimicrobial Activities Against Bovine Mastitis Staphylococcus aureus. Front Vet Sci. 2018 Jul 11;5:148. |