| Description | 2,4-Difluorobenzaldehyde can act on the light chain of botulinum neurotoxin type A (BoNT/A), inhibiting the cleavage of BoNT A light chain, ic50=4.9μM. |
| Synonyms | 2,4-Difluoro-benzaldehyde, 2,4-二氟苯甲醛 |
| molecular weight | 142.1 |
| Molecular formula | C7H4F2O |
| CAS | 1550-35-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 60 mg/ml (422.24 mM) |
| References | 1. Houdaihed L , Evans J , Allen C . Delivery of paclitaxel and everolimus in dual-targeted polymeric nanoparticles to breast cancer cells[J]. Annals of Oncology, 2018, 29(suppl_3). 2. Harrell Jr W A, et al. A matrix-focused structure-activity and binding site flexibility study of quinolinol inhibitors of botulinum neurotoxin serotype A. Bioorganic & Medicinal Chemistry Letters, 2017, 27(3): 675-678. |