| Description | 116-9e (MAL2-11B) is a potent Hsp70 co-chaperone DNAJA1 inhibitor with antiviral properties, inhibition of simian virus 40 (SV40) replication, inhibition of tumour antigen (TAg) endogenous ATPase activity, and TAg-mediated activation of Hsp70.116-9e can be used to study cancer drug resistance. |
| In vitro | 116-9e (MAL2-11B) 比 MAL3-101 更有效地抑制由 TAg 激活的 Hsp70，显著减少病毒复制和 DNA 合成。MAL2-11B 还抑制了 TAg ATPase 领域的活性[1]。在人类肾细胞系中，116-9e (MAL2-11B; 15 μM; 5天) 显著降低 BK 病毒水平[2]。 |
| Synonyms | MAL-2-11B, MAL2-11B, MAL211B, MAL 2 11B, MAL2 11B |
| molecular weight | 512.6 |
| Molecular formula | C31H32N2O5 |
| CAS | 831217-43-7 |
| Storage | |Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 80 mg/mL (156.07 mM), Sonication is recommended. |
| References | 1. Nitika, et al. Chemogenomic screening identifies the Hsp70 co-chaperone DNAJA1 as a hub for anticancer drug resistance. Sci Rep. 2020 Aug 14;10(1):13831. 2. Christine M Wright, et al. Inhibition of Simian Virus 40 replication by targeting the molecular chaperone function and ATPase activity of T antigen. Virus Res. 2009 Apr;141(1):71-80. |