| Description | 10,12-Tricosadiynoic acid is a highly selective and orally active inhibitor of acyl-CoA oxidase-1 (ACOX1). It can treat the high-fat diet- or obesity-induced metabolic diseases by improving mitochondrial lipid and ROS metabolism. |
| In vitro | 10,12-Tricosadiynoic acid 是 10,12-Tricosadiynoic acid-CoA 的前体，进入细胞后由过氧物酶体超长链酰基-CoA 合成酶（VLACS）转化为 10,12-Tricosadiynoic acid-CoA，在体内可抑制 ACOX1[1].10,12-Tricosadiynoic acid（500 nM）可抑制酰基-CoA 氧化酶-1（ACOX1）的活性。10,12-三羟基二炔酸会减弱Sirt5siRNA 的保护作用[2]。 |
| In vivo | 10,12-Tricosadiynoic acid（100 μg/kg；口腔灌胃；每日；为期8周；雄性Wistar大鼠）通过激活SIRT1-AMPK途径和增殖激活受体α来增加高脂饮食喂养大鼠肝脏线粒体脂肪酸氧化（FAO），减少过氧化氢的积累，降低肝脏脂质和ROS含量，减少体重增加，同时降低血清甘油三酯和胰岛素水平。 |
| Animal experiments | Animal Model: Male Wistar rats (210-230 g) fed with high-fat diet. Dosage: 100 μg/kg. Administration: Oral gavage; daily; for 8 weeks |
| Synonyms | TDA, TCDA |
| molecular weight | 346.55 |
| Molecular formula | C23H38O2 |
| CAS | 66990-30-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 2.75 mg/mL (7.94 mM) |
| References | 1. Zeng J, et al. Specific Inhibition of Acyl-CoA Oxidase-1 by an Acetylenic Acid Improves Hepatic Lipid and Reactive Oxygen Species (ROS) Metabolism in Rats Fed a High Fat Diet. J Biol Chem. 2017 Mar 3;292(9):3800-3809. |