| Description | 1-Stearoyl-2-arachidonoyl-sn-glycerol (DAG) is a diacylglycerol (DAG) substrate that can be hydrolyzed to 2-arachidonic acid glycerol. 1-Stearoyl-2-arachidonoyl-sn-glycerol activates PKC, induces Ca2+ influx, and can induce tracheal smooth muscle contraction. |
| In vitro | 1-Stearoyl-2-arachidonoyl-sn-glycerol (0.3-3 μM) 增强气道平滑肌细胞中非选择性阳离子通道 (NSCC) 活性；1-Stearoyl-2-arachidonoyl-sn-glycerol (0-5 μM) 对 PKCα、PKCδ、PKCγ、PKCε 和 PKCβI 的活化具有显著的刺激作用 [2] 。 |
| molecular weight | 645.01 |
| Molecular formula | C41H72O5 |
| CAS | 65914-84-3 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Song T, et, al. Inositol 1,4,5-trisphosphate activates TRPC3 channels to cause extracellular Ca2+ influx in airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2015 Dec 15;309(12):L1455-66. 2. Madani S, et, al. Implication of acyl chain of diacylglycerols in activation of different isoforms of protein kinase C. FASEB J. 2001 Dec;15(14):2595-601. 3. Glasmacher S, et, al. Characterization of pepcan-23 as pro-peptide of RVD-hemopressin (pepcan-12) and stability of hemopressins in mice. Adv Biol Regul. 2021 May;80:100808. |
1-Stearoyl-2-arachidonoyl-sn-glycerol
CAS No.: 65914-84-3
1-Stearoyl-2-arachidonoyl-sn-glycerol (DAG) is a diacylglycerol (DAG) substrate that can be hydrolyzed to 2-arachidonic
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