| Description | 1-Octanol, a saturated fatty alcohol, functions as an inhibitor of T-type calcium channels (T-channels), showing an inhibitory concentration (IC50) of 4 μM for native T-currents[1]. Additionally, 1-Octanol is recognized for its potential as a biofuel, possessing diesel-like properties[2]. |
| In vitro | 1-Octanol 在亚麻醉浓度下能抑制原生T型电流，其半抑制浓度大约为4 μM。相比之下，1-Octanol抑制异源表达在人胚肾细胞中的重组CaV3.3 T通道的效力最多低30倍[1]。 |
| Target activity | Ca2+ channel, T-type:4 μM |
| Synonyms | Octanol, 正辛醇 |
| molecular weight | 130.23 |
| Molecular formula | C8H18O |
| CAS | 111-87-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 50 mg/mL (383.94 mM), Sonication is recommended. |
| References | 1. Joksovic PM, et al. Mechanisms of inhibition of T-type calcium current in the reticular thalamic neurons by 1-octanol: implication of the protein kinase C pathway. Mol Pharmacol. 2010 Jan;77(1):87-94. 2. Akhtar MK, et al. Microbial production of 1-octanol: A naturally excreted biofuel with diesel-like properties. Metab Eng Commun. 2014 Nov 13;2:1-5. |