| Description | 1-Deazaadenosine is a potent Adenosine deaminase inhibitor (Ki: 0.66 μM). It exhibits anti-cancer activities in vitro and has the potential to be a chemotherapy agent for lymphoproliferative disorders. |
| In vitro | 1-Deazaadenosine shows good activity in vitro as an inhibitor of HeLa, KB, P388, and L1210 leukemia cell line growth (ID50s: 0.34 μM (KB) to 1.8 μM (P388)). |
| molecular weight | 266.25 |
| Molecular formula | C11H14N4O4 |
| CAS | 14432-09-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| References | 1. Cristalli G, et al.Adenosine deaminase inhibitors: Structure-activity relationships in 1-deazaadenosine and erythro-9-(2-hydroxy-3-nonyl)adenine analogues. Drug Dev.Res. 2. Cristalli G, et al.Improved synthesis and antitumor activity of 1-deazaadenosine.J Med Chem. 1987 Sep;30(9):1686-8. |