| Description | 1,3-bis(carboxyethoxy)-2,2-bis(carboxyethoxy)propane is a polyethylene glycol (PEG)-based linker compound suitable for the synthesis of proteolysis-targeting chimeras (PROTACs)[1]. |
| In vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
| Synonyms | 1-3-bis-carboxyethoxy-2-2-bis-carboxyethoxy-propane |
| molecular weight | 424.4 |
| Molecular formula | C17H28O12 |
| CAS | 35638-19-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
1,3-bis(carboxyethoxy)-2,2-bis(carboxyethoxy)propane
CAS No.: 35638-19-8
1,3-bis(carboxyethoxy)-2,2-bis(carboxyethoxy)propane is a polyethylene glycol (PEG)-based linker compound suitable for t
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