| Description | 1,2-Dipalmitoyl-sn-glycero-3-PE-N-(cap biotin) is a biotinylated phospholipid. It has been used in PEGylated polyamidoamine-dendrimer-conjugated supported lipid bilayers (SLB) to isolate circulating tumor cells and tumor cell microembolis from patient-derived blood by antibody-coated microfluidics. [1] It has also been used as a component of SLBs to detect protein-ligand binding with ortho-conjugated Texas Red DHPE. [2] In addition, 1,2-dipalmitoyl-sn-glycero-3-PE-N-(cap biotin) has been used in SLBs partitioned into nanowells to create DNA curtains, which can be used as a high-throughput tool for detection of protein-DNA interactions at the single molecule level.[3] |
| Synonyms | 1,2-Dipalmitoyl-sn-glycero-3-PE-N-(cap biotin) (sodium salt), biotin-cap-DPPE |
| molecular weight | 1054.42 |
| Molecular formula | C53H99N4NaO11PS |
| CAS | 384835-52-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: Slightly Soluble |
| References | 1. Yeh, P.-Y., Chen, Y.-R., Wang, C.-F., et al. Promoting multivalent antibody-antigen interactions by tethering antibody molecules on a PEGylated dendrimer-supported lipid bilayer. Biomolecules 19(2), 426-437 (2018). 2. Jung, H., Robison, A.D., and Cremer, P.S. Detecting protein-ligand binding on supported bilayers by local pH modulation. J. Am. Chem. Soc. 131(3), 1006-1014 (2009). 3. Visnapuu, M.-L., Fazio, T., Wind, S., et al. Parallel arrays of geometric nanowells for assembling curtains of DNA with controlled lateral dispersion. Langmuir 24(19), 11293-11299 (2008). |
1,2-Dipalmitoyl-sn-glycero-3-PE-N-(cap biotin) (sodium salt)
CAS No.: 384835-52-3
1,2-Dipalmitoyl-sn-glycero-3-PE-N-(cap biotin) is a biotinylated phospholipid. It has been used in PEGylated polyamidoam
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