| Description | Zeylenone, a cyclohexene oxide from Uvaria grandiflora, has antitumour and antiproliferative activity, inhibiting cervical cancer cell proliferation and inducing apoptosis through the PI3K/AKT/mTOR and MAPK/ERK signalling pathways. |
| In vitro | Zeylenone(zey)，一种环己烯氧化合物，在多个癌细胞系中表现出明显的抑制作用，并对正常细胞显示出很少的细胞毒性，使得 Zeylenone 能在联合治疗中发挥独特的作用。Zeylenone 增强了顺铂的抗骨肉瘤功效，并在体外表现出与顺铂的协同作用，这也在使用移植瘤模型的体内得到了验证[1]。 |
| molecular weight | 382.36 |
| Molecular formula | C21H18O7 |
| CAS | 193410-84-3 |
| Storage | keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Yang S,et al. Zeylenone synergizes with cisplatin in osteosarcoma by enhancing DNA damage, apoptosis, and necrosis via the Hsp90/AKT/GSK3β and Fanconi anaemia pathway. Phytother Res. 2021 Oct;35(10):5899-5918. 2. Zhang L, et al. Zeylenone, a naturally occurring cyclohexene oxide, inhibits proliferation and induces apoptosis in cervical carcinoma cells via PI3K/AKT/mTOR and MAPK/ERK pathways. Sci Rep. 2017 May 10;7(1):1669. |