| Description | Vasopressin (argipressin), a cyclic nine-peptide synthesized by hypothalamic neurons, is one of the hormones involved in peptide prohormone synthesis. Vasopressin is involved in the regulation process of hypothalamic-pituitary-adrenal axis, increasing the amount of solute free water reabsorbed from the renal tubule's colate back into the circulation, narrowing arteries to increase pressure, enhancing the stimulating effect of corticotropin releasing factor to regulate pituitary corticotropin secretion. Vasopressin acts as a neurotransmitter during nerve conduction by binding to specific G-protein-coupled receptors. |
| In vitro | AVP (0.01 nM-1 μM) triggers Ca2+ elevation in Chinese hamster ovary cells expressing either rat or human V1b receptors.[1] |
| In vivo | Vasopressin (0.03-0.3 μg/kg; i.p.) enhances corticotropin release elicited by exogenous corticoliberin and amplifies corticotropin secretion following dehydration.[1]Vasopressin (0.001-0.1 mg/kg; i.p.) significantly promotes proximity, wherein rats encountering each other for the first time exhibit passive side-by-side positioning.[2] |
| Synonyms | antidiuretic hormone (ADH), argipressin, arginine vasopressin (AVP) |
| molecular weight | 1084.24 |
| Molecular formula | C46H65N15O12S2 |
| CAS | 11000-17-2 |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 90.0 mg/mL (83.0 mM), Sonication is recommended. H2O: 45.0 mg/mL (41.5 mM), Sonication is recommended. |
| References | 1. Ramos L, et al. Acute prosocial effects of oxytocin and vasopressin when given alone or in combination with 3,4-methylenedioxymethamphetamine in rats: involvement of the V1A receptor. Neuropsychopharmacology. 2013;38(11):2249-2259. 2. Serradeil-Le Gal C, et al. Characterization of (2S,4R)-1-[5-chloro-1-[(2,4-dimethoxyphenyl)sulfonyl]-3-(2-methoxy-phenyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-4-hydroxy-N,N-dimethyl-2-pyrrolidine carboxamide (SSR149415), a selective and orally active vasopressin V1b receptor antagonist. J Pharmacol Exp Ther. 2002;300(3):1122-1130. 3. Gizowski C, et al. Central and peripheral roles of vasopressin in the circadian defense of body hydration. Best Pract Res Clin Endocrinol Metab. 2017;31(6):535-546. 4. Caldwell HK,et al. Social Context, Stress, Neuropsychiatric Disorders, and the Vasopressin 1b Receptor. Front Neurosci. 2017;11:567. 5. Terranova JI, et al. Sex Differences in the Regulation of Offensive Aggression and Dominance by Arginine-Vasopressin. Front Endocrinol (Lausanne). 2017;8:308. |