| Description | Urocortin, human (Human urocortin I) is a 40 amino acid peptide which is closely related to corticotrophin-releasing factor (CRF). |
| In vitro | Urocortin, human作为CRF2受体的选择性激动剂，在细胞试验中，对人类CRF1、大鼠CRF2α和小鼠CRF2β受体的Kis分别为0.4、0.3和0.5 nM[1]。 |
| In vivo | Urocortin（0.01至10μg）在食物匮乏和非匮乏的大鼠中减少食物摄入，且在小鼠中经脑室内给予1μg Urocortin后观察到类似效果。它似乎是一种更强的摄食行为抑制剂。Urocortin具有诱导焦虑行为的潜力[2]。 |
| Target activity | CRF2β (mouse): 0.5 nM, CRF1 (human):0.4nM, CRF2α (rat):0.3 nM |
| Synonyms | Urocortin (human), Human urocortin, Human urocortin 1, Human urocortin I |
| molecular weight | 4696.32 |
| Molecular formula | C204H337N63O64 |
| CAS | 176591-49-4 |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Reul JM, et al. Corticotropin-releasing factor receptors 1 and 2 in anxiety and depression. Curr Opin Pharmacol. 2002 Feb;2(1):23-33. 2. Skelton KH, et al. The neurobiology of urocortin. Regul Pept. 2000 Sep 25;93(1-3):85-92. |