| Description | Tributyrin (Glyceryl tributyrate), a neutral short-chain fatty acid triglyceride, is a stable and rapidly absorbed prodrug of Butyric Acid. Tributyrin diffuses through biological membranes and is metabolized by intracellular lipases, releasing effective butyrate directly into the cell in vivo. Tributyrin has potent proapoptotic, antiproliferative, and differentiation-inducing effects. |
| Synonyms | NSC661583, NSC 661583, NSC-661583, 甘油三丁酸酯 |
| molecular weight | 302.36 |
| Molecular formula | C15H26O6 |
| CAS | 60-01-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 100 mg/mL (330.73 mM), Sonication is recommended. |
| References | 1. Guariento AH, Furtado KS, de Conti A, Campos A, Purgatto E, Carrilho J, Shinohara EM, Tryndyak V, Han T, Fuscoe JC, Ross SA, Beland FA, Pogribny IP, Moreno FS. Transcriptomic responses provide a new mechanistic basis for the chemopreventive effects of folic acid and tributyrin in rat liver carcinogenesis. Int J Cancer. 2014 Jul 1;135(1):7-18. doi: 10.1002/ijc.28642. PubMed PMID: 24302446; PubMed Central PMCID: PMC4229010. 2. Cresci G, Nagy LE, Ganapathy V. Lactobacillus GG and tributyrin supplementation reduce antibiotic-induced intestinal injury. JPEN J Parenter Enteral Nutr. 2013 Nov;37(6):763-74. doi: 10.1177/0148607113486809. PubMed PMID: 23630018; PubMed Central PMCID: PMC3818407. 3. de Conti A, Tryndyak V, Koturbash I, Heidor R, Kuroiwa-Trzmielina J, Ong TP, Beland FA, Moreno FS, Pogribny IP. The chemopreventive activity of the butyric acid prodrug tributyrin in experimental rat hepatocarcinogenesis is associated with p53 acetylation and activation of the p53 apoptotic signaling pathway. Carcinogenesis. 2013 Aug;34(8):1900-6. doi: 10.1093/carcin/bgt124. PubMed PMID: 23568954. 4. Cresci GA, Bush K, Nagy LE. Tributyrin supplementation protects mice from acute ethanol-induced gut injury. Alcohol Clin Exp Res. 2014 Jun;38(6):1489-501. doi: 10.1111/acer.12428. PubMed PMID: 24890666; PubMed Central PMCID: PMC4185400. |