| Description | trans-Urocanic Acid ((E)-Urocanic acid), a compound predominantly distributed in the hippocampus and prefrontal cortex, is an isomer of cis-UCA, an epidermal UV-protectant, which enhances the stability of tenofovir eplerenomide in long-acting HIV applications. trans-Urocanic acid potently modulates immune trans-urocanic acid effectively modulates immune function, inhibits human natural killer cell activity in vitro, and can be used in Alzheimer's disease research. |
| In vitro | 在初级人角质形成细胞中，trans-Urocanic Acid（100 μg/mL；24 小时）能够降低细胞增殖和存活率[2]。 |
| Synonyms | trans-UCA, (E)-Urocanic acid |
| molecular weight | 138.12 |
| Molecular formula | C6H6N2O2 |
| CAS | 3465-72-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | PBS (pH 7.2): 0.3 mg/mL DMSO: 15 mg/mL DMF: 3 mg/mL |
| References | 1. J Uksila, et al. Trans-urocanic acid, a natural epidermal constituent, inhibits human natural killer cell activity in vitro. Exp Dermatol. 1994 Apr;3(2):61-5. 2. Kazuyo Kaneko, et al. cis-Urocanic acid enhances prostaglandin E2 release and apoptotic cell death via reactive oxygen species in human keratinocytes. J Invest Dermatol. 2011 Jun;131(6):1262-71. |