| Description | Toralactone is a natural product isolated from Cassia obtusifolia, mediates hepatoprotection via an Nrf2-dependent anti-oxidative mechanism |
| In vitro | Rubrofusarin与toralactone能通过抑制P-gp外泌活性并增强P-gp底物的细胞内陷阱作用来提高P-gp底物如PTX的细胞毒性特性。Toralactone通过抑制P-糖蛋白外泌活性使耐药性MCF-7adr细胞系对紫杉醇敏感[1]。 |
| molecular weight | 272.25 |
| Molecular formula | C15H12O5 |
| CAS | 41743-74-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Salwa D. Alqahtani, et al. Abstract 1205: Rubrofusarin and toralactone sensitize resistant MCF-7adr cell line to paclitaxel via inhibiting P-glycoprotein efflux activity. AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC. 2. YongtaekSeo, et al. Toralactone glycoside in Cassia obtusifolia mediates hepatoprotection via an Nrf2-dependent anti-oxidative mechanism. Food Research International. Volume 97, July 2017, Pages 340-346. |