| Description | Torachrysone-8-O-b-D-glucoside shows alpha-glucosidase inhibitory activities, it may be used for the management of type 2 diabetes. |
| In vitro | 开发了一种新型的体外α±-葡萄糖苷酶抑制活性检测方法，其基于使用麦芽糖作为底物。该新方法被用于测定何首乌(Polygonum multiflorum)及四种蒽醌化合物对α±-葡萄糖苷酶的抑制活性。结果显示，何首乌在0.0032 mg mL^-1浓度时，对α±-葡萄糖苷酶展示了50%的抑制效果；而大黄素、芦荟大黄素、大黄素酚和大黄酸等四种蒽醌化合物显示出强大的α±-葡萄糖苷酶抑制活性，其IC50值分别在4.12 μM至5.68 μM之间。此外，采用离心超滤联合LC-ESI-MSn技术，成功从何首乌提取物中筛选并鉴定出九种小分子活性化合物，作为潜在的α±-葡萄糖苷酶抑制剂。 |
| Synonyms | 芦荟大黄素 8-葡萄糖甙, Torachrysone 8-O-glucoside |
| molecular weight | 408.4 |
| Molecular formula | C20H24O9 |
| CAS | 64032-49-1 |
| Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 65 mg/ml (159.16 mM) |
| References | 1. The screening of potential α±-glucosidase inhibitors from the Polygonum multiflorum extract using ultrafiltration combined with liquid chromatography-tandem mass spectrometryAnal. Methods-UK. 2014, 6(10):3353-9. |