Thymosin β4 acetate(75591-33-4 free base)-product

Description	Thymosin β4 (Tβ4) is a thymic hormone with multiple and different intracellular and extracellular activities affecting wound healing, inflammation, fibrosis and tissue regeneration.
In vitro	Thymosin β4能够促进心肌细胞和内皮细胞的迁移，并增强心肌细胞的存活率。LIM结构域蛋白PINCH18和ILK19均为细胞迁移和存活所必需，它们与thymosin β4形成复合体，进而导致存活激酶Akt的磷酸化。
In vivo	在成年小鼠心脏结扎术后用Thymosin β4处理，结果显示心脏中Akt的磷酸化水平上升，早期心肌细胞存活率提高，心脏功能得到改善。
molecular weight	949.07
Molecular formula	C40H72N10O16
CAS	1346423-89-9
Storage	keep away from moisture　\|　Powder: -20°C for 3 years \| In solvent: -80°C for 1 year
Solubility	H2O: 5 mM DMSO: Insoluble
References	1. Renga G, Oikonomou V, Stincardini C, Pariano M, Borghi M, Costantini C, Bartoli A, Garaci E, Goldstein AL, Romani L. Thymosin β4 limits inflammation through autophagy. Expert Opin Biol Ther. 2018 Jul;18(sup1):171-175. doi: 10.1080/14712598.2018.1473854. 2. Bock-Marquette I, Saxena A, White MD, Dimaio JM, Srivastava D. Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair. Nature. 2004 Nov 25;432(7016):466-72. doi: 10.1038/nature03000.

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