| Description | Thymalfasin (Thymosin α1) (thymosin-alpha 1) is an immunomodulating agent able to enhance the Thl immune response. |
| In vitro | Thymalfasin在多种免疫功能失调的实验模型中展现出了有效性,主要包括传染病,例如,肝炎(woodchuck)和流感(mouse),以及癌症,如黑色素瘤(mouse)和结直肠癌(rat),在这些病例中,Thymalfasin展示了抗肿瘤效果[2]。 |
| In vivo | Thymalfasin 在多种免疫功能障碍的实验模型中显示出有效性,主要包括如肝炎(woodchuck)和流感(mouse)等传染病,以及如黑色素瘤(mouse)和结直肠癌(rat)等癌症,其中Thymalfasin 表现出抗肿瘤效果[2]。 |
| Synonyms | 胸腺法新, Thymosin α1, 醋酸胸腺α1 |
| molecular weight | 3108.28 |
| Molecular formula | C129H215N33O55 |
| CAS | 62304-98-7 |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | H2O: 0.3 mg/mL (0.10 mM), Sonication and heating are recommended. |
| References | 1. Lao X et al. A modified thymosin alpha 1 inhibits the growth of breast cancer both in vitro and in vivo: suppressment of cell proliferation, inducible cell apoptosis and enhancement of targeted anticancer effects. Apoptosis. 2015 Oct;20(10):1307-20. |