| Description | Thiamine nitrate (Vitamin B1 nitrate) is an essential vitamin, and can enhance normal neuronal actives. |
| In vitro | In the blood of homozygous KO and KI mice , Thiamine levels fed a conventional diet are decreased to 0.058±0.051 and 0.126±0.092 μM, respectively, at 7 weeks compared to WT mice (0.796±0.259 μM). When WT and homozygous KO and KI mice are fed a Thiamine-restricted diet (Thiamine: 0.60 mg/100 g food), blood Thiamine concentration at 5 and 14 days is markedly decreased to 0.010±0.009 and 0.010±0.006 μM, respectively, compared to WT mice (0.609±0.288 μM). Thiamine concentration in brain homogenate of WT mice fed a conventional diet is 3.81±2.18 nmol/g wet weight, and that of KO and KI is 1.33±0.96 and 2.16±1.55 nmol/g wet weight, respectively. It is worth noting that Thiamine concentration in brain homogenate decreases steadily in KO and KI mice fed a thiamine-restrict diet (Thiamine: 0.60 mg/100 g food) for 5 days (0.95±0.72 nmol/g wet weight) and 14 days (1.11±0.24 nmol/g wet weight), respectively, compare to WT (3.65±1.02 nmol/g wet weight), before the mice presenting an phenotype of disease[2]. |
| Synonyms | 硝酸硫胺, Vitamin B1 nitrate |
| molecular weight | 327.36 |
| Molecular formula | C12H17N5O4S |
| CAS | 532-43-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 4.62 mg/mL (14.1 mM), Sonication is recommended. |
| References | 1. Kenneth Osiezagha, et al.Thiamine Deficiency and Delirium. Innov Clin Neurosci. 2013 Apr; 10(4): 26-32. 2. Kaoru Suzuki, et al. High-dose thiamine prevents brain lesions and prolongs survival ofSlc19a3-deficient mice. PLoS One. 2017; 12(6): e0180279. |