| Description | Thermolysin is an extracellular metalloendopeptidase from Bacillus thermolysinophilus that selectively catalyzes short peptides. |
| In vivo | 在自发性高血压大鼠（SHR）中，Thermolysin（50 mg/kg；口服一次）能够降低 SHR 大鼠的收缩压，给药后 6 小时内收缩压最大下降 22 毫米汞柱[4]。 |
| molecular weight | N/A |
| CAS | 9073-78-3 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | H2O: 1 mg/mL, Sonication and adjust pH to 3 with HCl are recommended. |
| References | 1. Bertusvan den Burg, et al. Chapter 111 - Thermolysin and Related Bacillus Metallopeptidases. 2. Mu-Forster C, et al. Surface localization of zein storage proteins in starch granules from maize endosperm. Proteolytic removal by thermolysin and in vitro cross-linking of granule-associated polypeptides. Plant Physiol. 1998 Apr;116(4):1563-71. 3. Di Bernardini R, et al. Isolation, purification and characterization of antioxidant peptidic fractions from a bovine liver sarcoplasmic protein thermolysin hydrolyzate. Peptides. 2011 Feb;32(2):388-400. 4. Fujita H, et al: a prodrug-type ACE-inhibitory peptide derived from fish protein. Immunopharmacology. 1999 Oct 15;44(1-2):123-7. 5. Ke Q, et al. Safety evaluation of a thermolysin enzyme produced from Geobacillus stearothermophilus. Food Chem Toxicol. 2013 Sep;59:541-8. |