| Description | Theobromine (3,7-Dimethylxanthine), a xanthine alkaloid, is used as a bronchodilator and as a vasodilator. |
| In vitro | Theobromine (3,7-二甲基黄嘌呤)是一种黄嘌呤类生物碱，用作支气管扩张剂和血管扩张剂。[1] Theobromine利尿作用较茶碱弱，且对平滑肌的兴奋作用也较弱。[2] 与咖啡因不同，Theobromine对中央神经系统几乎无刺激效果，但可能通过周围生理改变提升情绪和认知功能。[3] Theobromine 曾用作利尿剂及治疗心绞痛和高血压的化合物。[4] |
| In vivo | LD50: 兔 >200 mg/kg（经口）[5] |
| Synonyms | 3, 7-Dimethylxanthine, 可可碱, 3,7-Dimethylxanthine |
| molecular weight | 180.16 |
| Molecular formula | C7H8N4O2 |
| CAS | 83-67-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 1mg/ml, Sonication is recommended. |
| References | 1. McGovern T, et al. J Clin Invest, 1936, 15(1), 11-16. 2. Kaur J, et al. J Inorg Biochem, 1992, 48(4), 305-310. 3. Mitchell ES, et al. Physiol Behav, 2011, 104(5), 816-822. 4. Batterman RC, et al. Int Rec Med Gen Pract Clin, 1959, 172(6):318-323. 5. Tarka SM Jr, et al. Food Chem Toxicol, 1986, 24(5), 363-374. 6. Martín-Peláez S, et al. Effect of cocoa's theobromine on intestinal microbiota of rats. Mol Nutr Food Res. 2017 Oct;61(10). |