| Description | Tetrandrine (Sinomenine A) is a natural, bis-benzylisoquinoline alkaloid isolated from the root of the plant. Tetrandrine non-selectively inhibits calcium channel activity and induces G1 blockade of the G1 phase of the cell cycle and apoptosis in various cell types, resulting in immunosuppressive, anti-proliferative and free radical scavenging effects. |
| In vitro | 在小鼠中,静脉注射Tetrandrine的LD50为158.9 mg/kg ,腹腔注射Tetrandrine的LD50为365 mg/kg;在大鼠中,灌胃Tetrandrine的LD50为646 mg/kg. |
| In vivo | 在大鼠神经垂体分离的神经末梢中（IC50=10.1 mM）,Tetrandrine 抑制电压门控的Ca2 +电流。Tetrandrine 是大鼠神经垂体终端maxi-Ca（2 +）激活的K +通道II型（IC50=0.21 mM）的高亲和性阻断剂。Tetrandrine还能够抑制Ca（2 +）激活的Cl-电流（IC50=5.2 mM）。在人白血病HL-60细胞中,Tetrandrine能够抑制细胞增殖,诱导细胞凋亡。 |
| Synonyms | NSC-77037, d-Tetrandrine, Hanfangchin A, 粉防己碱, Fanchinine, Sinomenine A, 汉防己甲素 |
| molecular weight | 622.75 |
| Molecular formula | C38H42N2O6 |
| CAS | 518-34-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 50 mg/mL (80.29 mM) |
| References | 1. Wang G, et al. Pflugers Arch, 1992, 421(6), 558-565. 2. Fang QZ, et al. Acta Pharmacol Sin, 2004, 25(3), 327-333. 3. Dong Y, et al. Life Sci, 1997, 60(8), PL135-140. |