| Description | (±)-Taxifolin ((±)-Dihydroquercetin) is the racemate of Taxifolin, a flavonoid commonly found in onion, silymarin, French maritime pine bark, and Douglas fir bark, with anti-tyrosinase and anti-fibrotic activity.Taxifolin is an inhibitor of collagenase, with an IC 50 value of 193.3 μM. Taxifolin is a free radical scavenger with antioxidant capacity. |
| In vivo | Taxifolin（10 mg/kg；AD模型小鼠）处理显著阻止了Aβ42降低PSD 95表达水平的现象。活细胞成像研究显示，Taxifolin预处理2小时有效防止了Aβ42寡聚体导致的树突棘和突触小脚数量减少。[3] |
| Target activity | Collagenase:193.3 μM |
| Synonyms | (±)-Dihydroquercetin |
| molecular weight | 304.25 |
| Molecular formula | C15H12O7 |
| CAS | 24198-97-8 |
| Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | Ethanol: 18.0 mg/mL (59.1 mM) |
| References | 1. Angelis A, et al. Bio-Guided Isolation of Methanol-Soluble Metabolites of Common Spruce (Picea abies) Bark by-Products and Investigation of Their Dermo-Cosmetic Properties. Molecules. 2016 Nov 21;21(11):1586. 2. Lei Ren, et al. Dissecting Efficacy and Metabolic Characteristic Mechanism of Taxifolin on Renal Fibrosis by Multivariate Approach and Ultra-Performance Liquid Chromatography Coupled With Mass Spectrometry-Based Metabolomics Strategy. Front Pharmacol. 2021 Jan 14;11:608511. 3. Wang Y, et al. Taxifolin prevents β-amyloid-induced impairments of synaptic formation and deficits of memory via the inhibition of cytosolic phospholipase A2/prostaglandin E2 content. Metab Brain Dis. 2018;33(4):1069-1079. 4. Yang CL, et al. Hepatoprotective Mechanisms of Taxifolin on Carbon Tetrachloride-Induced Acute Liver Injury in Mice. Nutrients. 2019;11(11):2655. |