| Description | Synephrine (Oxedrine) is sympathetic alpha-adrenergic agonist used as a vasoconstrictor in circulatory failure, asthma, nasal congestion, and glaucoma. |
| In vitro | Synephrine通常用于减肥。作为ephedrine的替代品，Synephrine获得了显著的流行度。含有苦橙或Synephrine的产品被怀疑可能导致不良的心血管反应。[1] [2] 在L6骨骼肌细胞中，Synephrine能通过激活AMPK活性来刺激葡萄糖消耗（Glut4依赖的葡萄糖吸收），这一过程与胰岛素刺激的PI3激酶-Akt活动无关。[3] |
| In vivo | LD50：小鼠>1000 mg/kg（皮下注射）[4]。 |
| Synonyms | 辛弗林, Oxedrine |
| molecular weight | 167.21 |
| Molecular formula | C9H13NO2 |
| CAS | 94-07-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | Ethanol: 2 mg/mL (11.96 mM), Heating is recommended. DMSO: 31 mg/mL (185.4 mM) |
| References | 1. Stohs SJ, et al. Int J Med Sci, 2012, 9(7), 527-538. 2. Haaz S, et al. Obes Rev, 2006, 7(1), 79-88. 3. Hong NY, et al. Biochem Biophys Res Commun, 2012, 418(4), 720-724. 4. Unna K, et al. Archivfuer Experimentelle Pathologie und Pharmakologie, 1951, 213, 207-234. |