| Description | Sunset Yellow FCF (Sunset yellow) is an orange azo dye with pH-dependent absorbance.Sunset Yellow FCF is used in food, cosmetics and pharmaceuticals.It is used as a colorant food additive in many food products.They may be cytotoxic and genotoxic, so care must be taken when using these materials as food additives. |
| In vitro | Sunset Yellow FCF (250 μg/ml) 抑制了由LPS诱导的小鼠分离脾细胞的增生，并且在异基因混合淋巴细胞反应中也阻止了小鼠分离脾细胞的增生。[3] |
| In vivo | Sunset yellow FCF（0.325 mg/kg；小鼠）在小鼠体内引发体细胞和生殖细胞的染色体畸变以及精子形态异常，但在最高达2,000 mg/kg剂量下，通过小鼠微核肠道实验显示其并不具有遗传毒性。[4] |
| Synonyms | Food Yellow 3, Orange Yellow S, Sunset yellow, CI 15985 |
| molecular weight | 454.39 |
| Molecular formula | C16H12N2Na2O7S2 |
| CAS | 2783-94-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | H2O: 90.0 mg/mL (199.0 mM), Sonication is recommended. DMSO: 50 mg/mL (110.04 mM) |
| References | 1. Kus E, et al. Genotoxic and cytotoxic effects of Sunset Yellow and Brilliant Blue, colorant food additives, on human blood lymphocytes.Pak J Pharm Sci. 2015 Jan;28(1):227-30. 2. Ghoneim M M, et al. Electro-Fenton oxidation of Sunset Yellow FCF azo-dye in aqueous solutions. Desalination, 2011, 274(1-3): 22-30. 3. Yadav A, et al. Sunset yellow FCF, a permitted food dye, alters functional responses of splenocytes at non-cytotoxic dose. Toxicol Lett. 2013;217(3):197-204. 4. Sayed HM, et al. The modifying effect of selenium and vitamins A, C, and E on the genotoxicity induced by sunset yellow in male mice. Mutat Res. 2012;744(2):145-153. |