| Description | Sulfuretin is a potent anti-oxidant, has protective effect against t-BHP-induced oxidative damage in human liver-derived HepG2 cells is attributable to its ability to scavenge ROS and up-regulate the activity of HO-1 through the Nrf2/ARE and JNK/ERK signaling pathways. |
| In vitro | 在本研究中，我们探究了Sulfuretin对叔丁基过氧化物(t-BHP)诱导的氧化损伤的保护效果。结果表明，Sulfuretin的添加在t-BHP处理前显著抑制了人类肝脏衍生的HepG2细胞的细胞毒性和活性氧(ROS)的产生。通过核因子E2相关因子2 (Nrf2)的核内转移，Sulfuretin上调了抗氧化酶血红素氧合酶(HO)-1的活性，并增加了抗氧化反应元件(ARE)的启动子活性。此外，Sulfuretin暴露增强了c-Jun末端激酶(JNK)和细胞外信号调节激酶1/2 (ERK1/2)的磷酸化，这两者是丝裂原活化蛋白激酶(MAPK)家族的成员。进一步地，细胞处理中使用JNK抑制剂(SP600125)和ERK抑制剂(PD98059)减少了Sulfuretin诱导的HO-1表达，并降低了其保护效果。 |
| Synonyms | 硫黄菊素 |
| molecular weight | 270.24 |
| Molecular formula | C15H10O5 |
| CAS | 120-05-8 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 10 mM |
| References | 1. The cytoprotective effect of sulfuretin against tert-butyl hydroperoxide-induced hepatotoxicity through Nrf2/ARE and JNK/ERK MAPK-mediated heme oxygenase-1 expression.Int J Mol Sci. 2014 May 19;15(5):8863-77. |