| Description | Suffruticosol A, a neuroprotective compound isolated from the seeds of P. lactiflora [1], mitigates scopolamine-induced neurodegenerative cellular damage and improves hippocampal cholinergic function. Additionally, it partially boosts BDNF signaling and has neuromodulatory effects, leading to the restoration of memory and cognitive performance in a scopolamine-induced mouse model. |
| In vitro | Suffruticosol A（20 μM；24小时）能够逆转由2mM东莨菪碱处理导致的人神经母细胞瘤SH-SY5Y细胞的活力及存活率下降[1]。 |
| In vivo | Suffruticosol A（4 或 15 ng，每周两次；注射至大脑第三脑室）能缓解因东莨菪碱（1.0 mg/kg；腹腔注射）引发的小鼠认知与记忆障碍相关的神经效应[1]。 |
| molecular weight | 680.7 |
| Molecular formula | C42H32O9 |
| CAS | 220936-82-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |