| Description | (+)-Sophoranol exhibits antiviral activity against the Coxsackie virus B3. It also shows potent anti-HBV activity with an inhibitory potency against HBsAg secretion and against HBeAg secretion. |
| In vitro | CONCLUSIONS:Three new matrine-type alkaloids, (+)-5α±-hydroxyoxysophocarpine (1), (-)-12β-hydroxyoxysophocarpine (2), and (+)-5α±-hydroxylemannine (3), along with 14 known analogues, (-)-sophocarpine (4), (-)-5α±-hydroxysophocarpine (5), (-)-9α±-hydroxysophocarpine (6), (+)-12α±-hydroxysophocarpine (7), (-)-12β-hydroxysophocarpine (8), (+)-oxysophocarpine (9), (+)-matrine (10), (+)-Sophoranol (11), (+)-9α±-hydroxymatrine (12), (-)-14β-hydroxymatrine (13), (+)-oxymatrine (14), (+)-5α±-hydroxyoxymatrine (15), (-)-14β-hydroxyoxymatrine (16), and (+)-sophoramine (17), were isolated from the rhizomes of Sophora tonkinensis. Their structures were elucidated via spectrometric data analyses, and the absolute configurations were established by single-crystal X-ray diffraction and ECD data[1] |
| Target activity | RSV:10.4 μg/mL (IC50) |
| Synonyms | 槐醇, (+)-Sophoranol |
| molecular weight | 264.36 |
| Molecular formula | C15H24N2O2 |
| CAS | 3411-37-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Antiviral Matrine-Type Alkaloids from the Rhizomes of Sophora tonkinensis.J Nat Prod. 2015 Jul 24;78(7):1683-8. |