| Description | Sophocarpine monohydrate, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects. |
| In vitro | Sophocarpine exerts anti-cachectic effects by inhibiting TNF-α and IL-6 production in both RAW264.7 cells and murine primary macrophages. [1] Sophocarpine also shows antivirus activity by inhibiting HHV-6 replication in Molt-3 cells. [2] In addition, Sophocarpine is a potent blocker of HERG K+ channels with an IC50 of about 200 mM. [3] |
| In vivo | 给BALB/c小鼠种植colon26腺癌异种移植物后，自恶病质起始时起，连续5天每天以50 mg/kg的剂量给予Sophocarpine，并未能抑制肿瘤生长，但能减轻恶病质症状。[1] LD50：小鼠63.94 mg/kg（静脉注射）[4] |
| Synonyms | 槐果碱, Sophocarpine, 槐果碱水合物 |
| molecular weight | 246.35 |
| Molecular formula | C15H22N2O |
| CAS | 145572-44-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 60 mg/mL (243.56 mM) |
| References | 1. Zhang Y, et al. Int Immunopharmacol, 2008, 8(13-14), 1767-1772. 2. Qavi HB, et al. Phytother Res, 2002, 16(2), 154-156. |