| Description | Solamargine (δ-Solanigrine) is a major steroidal alkaloid glycoside extracted from a traditional Chinese medicine herb, Solanum nigrum L. (SNL); has been shown to inhibit growth and induce apoptosis of various cancer cells. |
| In vitro | Solamargine concentration-dependently reduced HepG2 cell viability. Solamargine (7.5 μM) reduced cell viability by less than 20% in HepG2 cells. Solamargine (highest dose) decreased cell invasion and migration by more than 72% and 70% in HepG2 cells, respectively. Solamargine reduced function and expression of MMP-2/9 proteins. Solamargine time-dependently increased phosphorylation of p38 mitogen-activated protein kinase (p38 MAPK) in a fashion. |
| Synonyms | Solamargin, δ-Solanigrine, 澳洲茄边碱 |
| molecular weight | 868.06 |
| Molecular formula | C45H73NO15 |
| CAS | 20311-51-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 91 mg/mL(104.8 mM) |
| References | 1. Sani IK., et al. Solamargine inhibits migration and invasion of human hepatocellular carcinoma cells through down-regulation of matrix metalloproteiN/Ases 2 and 9 expression and activity. Toxicol In Vitro. 2015 Aug;29(5):893-900. 2. Zhou Y, et al. Targeting sigN/Al transducer and activator of transcription 3 contributes to the solamargine-inhibited growth and -induced apoptosis of human lung cancer cells. Tumour Biol. 2014 Aug;35(8):8169-78. 3. Ding X, et al. Induction of apoptosis in human hepatoma SMMC-7721 cells by solamargine from Solanum nigrum L. J Ethnopharmacol. 2012 Jan 31;139(2):599-604. |