| Description | Silymarin (Silybin B) (Silybin B) is a polyphenolic flavonoid that extracts from the milk thistle or seeds of Silybum marianum. It is used in the prevention and treatment of liver diseases. |
| In vitro | Mechanism of Silymarin involves different biochemical reactions, such as stimulation of the rate of ribosomal RNA synthesis by stimulating the transcription of polymerase I and ribosomal RNA genes, blockage of alpha-glycoside loops toxin intake, and protection of cell membranes from free radical-induced damage. Silymarin also displays a substantial protective effect against UVB-induced canceration at different stages, possibly through its strong antioxidant properties. |
| In vivo | Silymarin 的静脉注射LD50分别对于小鼠、大鼠、兔子为391.4 mg/kg、70.1 mg/kg、142.3 mg/kg。 |
| Synonyms | Silybin B, 水飞蓟素 |
| molecular weight | 482.44 |
| Molecular formula | C25H22O10 |
| CAS | 65666-07-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 45 mg/mL (93.28 mM) H2O: < 1 mg/mL (insoluble or slightly soluble) Ethanol: 1 mg/mL (2.07 mM) |
| References | 1. Feher J, et al. Curr Pharm Biotechnol, 2012, 13(1), 210-217. 2. Wellington K, et al. BioDrugs, 2001, 15(7), 465-489. 3. Katiyar SK, et al. J Natl Cancer Inst, 1997, 89(8), 556-566. |