| Description | Sennoside A (NSC-112929), a kind of irritant laxative isolated from rhei rhizome, causes purgative actions in the intestine. |
| In vitro | Sennoside A，一种从大黄根茎中分离出的刺激性泻药，通过调节结肠的自发运动产生通便作用。[2] 它对牛血清单胺氧化酶具有轻微的抑制作用，其IC50为17 μM。[1] |
| In vivo | LD50：小鼠5000 mg/kg（i.g.）；大鼠5000 mg/kg（i.g.）。[3] |
| Target activity | MAO:17 μM |
| Synonyms | 番泻苷A, NSC 112929, 番泻苷 A |
| molecular weight | 862.74 |
| Molecular formula | C42H38O20 |
| CAS | 81-27-6 |
| Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | H2O: < 1 mg/mL (insoluble or slightly soluble) DMSO: 95 mg/mL (110.1 mM) Ethanol: < 1 mg/mL (insoluble or slightly soluble) |
| References | 1. Hiraoka A, et al. Chem Pharm Bull, 1989, 37(10), 2744-2746. 2. Kobayashi M, et al. Basic Clin Pharmacol Toxicol, 2007, 101(2), 121-126. 3. Mengs U, et al. Pharmacology, 1988, 36(Suppl. 1), 180-187. |