| Description | Cytidine 5'-triphosphate disodium salt is one of the endogenous metabolites and is a cation-permeable ligand-gated ion channel agonist. |
| In vitro | 细胞毒性在无外源性Ca2+环境下比存在外源性Ca2+时更高，表明Senecionine引起的肝脏毒性是由于细胞内Ca2+分布的改变，而非外源性Ca2+的流入所致[1]。 |
| In vivo | Senecionine未能激活环氧化酶，它降低了谷胱甘肽-S-转移酶、氨基吡啶去甲基酶以及AHH的活性[2]。每周两次注射Senecionine，从第12天或之后开始，在七只大鼠中有三只发生早产，所有窝的幼仔均为死胎或出生后不久即死亡[3]。 |
| Animal experiments | Swiss albino rats weighing 155-175 g are incubated for 3 consecutive days with seneciphylline and senecionine at a daily dose of 40 or 80 mg/kg body wt. Control animals received normal saline only. The animals are killed 24 h after the last dose. The livers are removed, weighed and then homogenized in 1.15% KCI, 0.02 HEPES (pH 7.4) [4]. |
| Synonyms | Aureine, Senecionan-11,16-dione, 12-hydroxy-, 千里光宁, Senecionin |
| molecular weight | 335.39 |
| Molecular formula | C18H25NO5 |
| CAS | 130-01-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | Ethanol: 1 mg/mL (2.98 mM) DMSO: 5 mg/mL (14.91 mM) |
| References | 1. D S Griffin, et al. Effects of the Pyrrolizidine Alkaloid Senecionine and the Alkenals trans-4-OH-hexenal and trans-2-hexenal on Intracellular Calcium Compartmentation in Isolated Hepatocytes. Biochem Pharmacol. 1989 Feb 1; 38 (3), 391-7 2. Kakrani HK, et al. Effect of seneciphylline and senecionine on hepatic drug metabolizing enzymes in rats. J Ethnopharmacol. 1984 Dec;12(3):271-8. 3. Tu ZB, et al. Identification of senecionine and senecionine N-oxide as antifertility constituents in Senecio vulgaris. J Pharm Sci. 1988 May;77(5):461-3. 4. Wang C, et al. The comparative pharmacokinetics of two pyrrolizidine alkaloids, senecionine and adonifoline, and their main metabolites in rats after intravenous and oral administration by UPLC/ESIMS. Anal Bioanal Chem. 2011 Jul;401(1):275-87. |