| Description | Scyllo-Inositol (Scyllitol) is one of the inositol stereoisomers, rare in the nature, and expected as a promising disease-modifying therapeutic agent for Alzheimer's disease. |
| In vitro | scyllo-inositol,an established amyloid inhibitor, ?was examined for potential inhibitory effects on α-synuclein aggregation.?TEM analysis of protein:inhibitor assays demonstrated that scyllo-inositol inhibits the aggregation of α-synuclein, suggesting the therapeutic potential of the small molecule in PD[1]. |
| Synonyms | Scyllitol, 鲨肌醇 |
| molecular weight | 180.16 |
| Molecular formula | C6H12O6 |
| CAS | 488-59-5 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | H2O: 2.5 mM DMSO: Insoluble |
| References | 1. Ibrahim T , Mclaurin J A . α-Synuclein aggregation, seeding and inhibition by scyllo-inositol[J]. Biochemical & Biophysical Research Communications, 2015:S0006291X15310482. 2. Yoshida KI, Ishikawa S.Production of scyllo-Inositol: Conversion of Rice Bran into a Promising Disease-Modifying Therapeutic Agent for Alzheimer's Disease.J Nutr Sci Vitaminol (Tokyo). 2019;65(Supplement):S139-S142. |