| Description | Sanguisorbigenin (Tomentosolic acid) is a natural antimicrobial agent that inhibits methicillin-resistant Staphylococcus aureus (MRSA). |
| In vitro | Sanguisorbigenin 在亚最小抑菌浓度（1.56-6.25 μg/mL）下处理，明显剂量依赖性地抑制了MRSA中blaR1、mecA和blaZ的表达。mecA基因表达在Sanguisorbigenin处理后显著降低。Sanguisorbigenin对六株S. aureus的最小抑菌浓度值范围为12.5-50 μg/mL[1]。Sanguisorbigenin具有强大的抗菌效果，并能通过抑制mecA表达和降低PBP2a表达有效逆转抗生素耐药性[1]。 |
| Synonyms | 地榆皂苷元, Tomentosolic acid, 3β-Hydroxyurs-12,19-dien-28-oic acid, 19-Dehydroursolic acid, Ursa-12,19-dien-28-oic acid |
| molecular weight | 454.68 |
| Molecular formula | C30H46O3 |
| CAS | 6812-98-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 60 mg/ml (127.48 mM) |
| References | 1. S Wang, et al. Antibacterial activity and synergy of antibiotics with sanguisorbigenin isolated from Sanguisorba officinalis L. against methicillin-resistant Staphylococcus aureus. Lett Appl Microbiol. 2021 Mar;72(3):238-244. |