| Description | Salidroside (Rhodioloside) is a bioactive phenolic glycoside compound isolated from Rhodiola crenulata. It is a prolyl endopeptidase Inhibitor. |
| In vitro | 20, 50 和100 mg/kg Salidroside保护肝脏组织免受D-半乳糖胺和LPS引起的氧化应激. |
| In vivo | Salidroside能够引起不同癌细胞系中G1期和G2期的停滞,同时,Salidroside降低CDK4,cyclin D1,cyclin B1和Cdc2,并上调p27（Kip1）和p21（Cip1）的水平。Salidroside浓度和时间依赖性抑制各种人类癌细胞系的生长。Salidroside激活PI3K/Akt通路,导致对MPP（+）诱导的PC12细胞凋亡的保护作用,其可用于治疗帕金森氏病（PD）。通过激活ERK1/2途径和抑制半胱氨酸蛋白酶-3激活,Salidroside还能减少H2O2刺激诱导培养的NGF分化的PC12细胞的细胞活力损失和凋亡性细胞死亡。 |
| Synonyms | 红景天苷, Rhodioloside |
| molecular weight | 300.3 |
| Molecular formula | C14H20O7 |
| CAS | 10338-51-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 55 mg/mL (183.15 mM) Ethanol: 4 mg/mL (13.32 mM) H2O: 55 mg/mL (183.2 mM) |
| References | 1. Hu X, et al. Cell Biol Toxicol, 2010, 26(6), 499-507. 2. Yu S, et al. J Mol Neurosci, 2010, 40(3), 321-331. 3. Zhang L, et al. Food Chem Toxicol, 2012, 50(8), 2591-2597. 4. Wu YL, et al. J Pharm Pharmacol, 2009, 61(10), 1375-1382. 6. Ju L, et al. Salidroside, A Natural Antioxidant, Improves β-Cell Survival and Function via Activating AMPK Pathway. Front Pharmacol. 2017 Oct 18;8:749. 7. Wu L, et al. Salidroside Protects against MPP+-Induced Neuronal Injury through DJ-1-Nrf2 Antioxidant Pathway. Evid Based Complement Alternat Med. 2017;2017:5398542. |